DropBrigt® HEPES: The Multi-Tasking "Buffer-Plus" for Brighter, Smoother Skin

August 07, 2025

Unlock the hidden potential of formulations with DropBrigt^® HEPES (INCI: Hydroxyethylpiperazine Ethane Sulfonic Acid, CAS 7365-45-9)—a bio-compatible buffer that transcends pH control to deliver exfoliation, brightening, and UV-protective synergy. Backed by cutting-edge 3D skin models, here’s why this versatile active belongs in your next brightening or anti-aging formula.

🌟 Triple-Action Benefits

Gentle Exfoliation
- Weak acid (pH 4.5–6.5) with macromolecular AHA-like properties.
- Softens keratinocytes, smooths texture, and boosts cell turnover without irritation at recommended doses (0.5–5%).
Clinical Brightening Power
- Proven Synergy: In 3D melanin skin models, formulations with HEPES + tranexamic acid + AA2G + niacinamide (Composition A):
  - ↑ L* value (brightness) by 15% vs. controls (P<0.01)
  - ↓ Melanin content by 30% (P<0.01)
  - Outperformed fewer-actives combos (B/C) in reducing UV-induced pigmentation.
UV Absorption & Penetration Boost
- Absorbs UVA/visible light, offering secondary photoprotection.
- Enhances delivery of co-actives (e.g., vitamin C, niacinamide).

🔬 Science Spotlight: Brightening Synergy

Test Parameter	Composition A	Composition B	Composition C
Tranexamic Acid	3%	–	–
AA2G	1%	1%	–
Niacinamide	2%	5%	6%
HEPES	0.5%	0.5%	0.5%
Result vs. UV-Damaged Skin	↑ L* value 15% ↓ Melanin 30%	Moderate improvement	Minimal impact

Key Insight: HEPES amplifies brightening efficacy in multi-active systems—0.5% HEPES doubled melanin reduction vs. niacinamide-only formulas.

⚙️ Formulator-Friendly Profile

Solubility: Water-soluble (1M solution: clear, colorless).
Stability: Heat/light-stable; pH 4–8 compatible.
Addition: Flexible—cold or hot process (≤80°C).
Safety:
- Mild irritation (IS=4.77 at 2% in chicken embryo test).
- Optimal use: 0.5–2% in leave-on products.

✅ Premium Quality Standards

Parameter	Specification
Appearance	White crystalline powder
Purity (Assay)	≥99.5%
Heavy Metals	≤10 ppm (Pb ≤2 ppm)
Microbials	Complies with ISO 11930
Shelf Life	2 years (room temp, sealed)

💡 Why Choose DropBrigt^® HEPES?

Beyond buffering, this "smart" active:

Rescues UV-stressed skin via melanin suppression.
Boosts actives’ efficacy in serums, toners, and creams.
Works synergistically with brightening powerhouses (vitamin C, tranexamic acid).
Simplifies formulating with water solubility and process flexibility.